Cellular Potts modeling of complex multicellular behaviors in tissue morphogenesis
نویسندگان
چکیده
منابع مشابه
Cellular Potts modeling of complex multicellular behaviors in tissue morphogenesis.
Mathematical modeling is an essential approach for the understanding of complex multicellular behaviors in tissue morphogenesis. Here, we review the cellular Potts model (CPM; also known as the Glazier-Graner-Hogeweg model), an effective computational modeling framework. We discuss its usability for modeling complex developmental phenomena by examining four fundamental examples of tissue morpho...
متن کاملMulti-Scale Modeling in Morphogenesis: A Critical Analysis of the Cellular Potts Model
Cellular Potts models (CPMs) are used as a modeling framework to elucidate mechanisms of biological development. They allow a spatial resolution below the cellular scale and are applied particularly when problems are studied where multiple spatial and temporal scales are involved. Despite the increasing usage of CPMs in theoretical biology, this model class has received little attention from ma...
متن کاملMulticellular rosette formation links planar cell polarity to tissue morphogenesis.
Elongation of the body axis is accompanied by the assembly of a polarized cytoarchitecture that provides the basis for directional cell behavior. We find that planar polarity in the Drosophila embryo is established through a sequential enrichment of actin-myosin cables and adherens junction proteins in complementary surface domains. F-actin accumulation at AP interfaces represents the first bre...
متن کاملMultiple interactions determine cellular electrical processes in the multicellular tissue.
See article by Verkerk et al. [5] (pages 30 –40) in this be achieved through novel experimental strategies or the issue. use of computer modeling. The article by Verkerk et al. in this issue of Cardiovascular Research [5] uses an elegant experimental ‘‘Things should be made as simple as possible, but preparation, developed in Ron Joyner’s laboratory and not any simpler’’ Albert Einstein used pr...
متن کاملModeling Tissue Morphogenesis and Cancer in 3D
Three-dimensional (3D) in vitro models span the gap between two-dimensional cell cultures and whole-animal systems. By mimicking features of the in vivo environment and taking advantage of the same tools used to study cells in traditional cell culture, 3D models provide unique perspectives on the behavior of stem cells, developing tissues and organs, and tumors. These models may help to acceler...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Development, Growth & Differentiation
سال: 2017
ISSN: 0012-1592,1440-169X
DOI: 10.1111/dgd.12358